Marek Hamsik gave hosts Napoli an early lead 10 minutes into the game before Paolo Cannavaro and a Davide Astori own goal made it 3-0 as they galloped towards a fifth straight league win.
Napoli shot to the top of Serie A with a controversial 3-0 win at 10-man Inter Milan on Saturday as Claudio Ranieri suffered his first defeat in charge and was sent off at halftime.
Serie A leaders AC Milan slipped up for the second straight game in a 1-1 draw at Genoa on Sunday which opened the door for Napoli to cut the gap at the top to three points.
Two goals in three minutes from Napoli's Goran Pandev were not enough to secure victory as his side threw away a two-goal lead to draw 3-3 at home to Udinese in an end-to-end Serie A thriller on Saturday.
Two goals in three devastating second-half minutes helped Napoli reach the Italian Cup final on Wednesday with a 3-0 win over AS Roma in the second leg of their semi-final in Naples, to clinch the tie 5-3 on aggregate.
Gonzalo Higuain netted twice, the first a superb individual effort, to give Napoli a 4-2 win at Lazio while Fiorentina beat Hellas Verona 4-3 in a Serie A scoring spree on Monday.
Lazio survived a storming Napoli fight back, including a missed penalty, as they won 4-2 on Sunday to finish third in Serie A and qualify for the Champions League playoff round after both teams finished with 10 men.
New Liverpool boss Juergen Klopp made it three wins from his last three matches with a 1-0 success at Rubin Kazan in Russia that left them second in Group B, two points behind Swiss club Sion on Thursday.